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4 Yourabusedbitch 29.%D2%BB%B8%F6%CF%F1%CF%C4%CC%EC%D2%BB%B8%F6%CF%F1%C7%EF%CC%EC%B4%AE%B4%CAXsearcha and H. S. Song, JETP Lett. 88, 319-322 (2008).
10、Four-dimensional entangled state generation in remote cavities
J. Song, Y. Xia, H. S. Song, and B. Liu, Euro. Phys. J D, 50, 91 (2008).
11、Optical protocol for quantum state sharing of superposed coherent state
Y. Xia, J. Song, and H. S. Song, J Mod. Opt. 55, 2071-2082 (2008).
12、Quantum state sharing using linear optical elements,
Y. Xia, J. Song, and H. S. Song, Opt. Commun. 281, 4946-4950 (2008).
13、Schemes for Greenberger-Horne-Zeilinger and cluster states preparation
J. Song, Y. Xia, and H. S. Song, J. Phys. B: At. Mol. Opt. Phys. 41, 065507 (2008).
15、Entangled state generation via adiabatic passage in two distant cavities
J. Song, Y. Xia, and H. S. Song, J. Phys. B: At. Mol. Opt. Phys. 40, 4503 (2007).
16、Controlled quantum secure direct communication using a non-symmetric quantum channel with quantum superdense coding
Y. Xia and H. S. Song, Phys. Lett. A 364, 117 (2007).
17、Multiparty remote state preparation
Y. Xia, J. Song, and H. S. Song, J. Phys. B: At. Mol. Opt. Phys. 40, 3719 (2007).
18、Secure direct communication based on secret transmitting order of particles
A. D. Zhu, Y. Xia, Q. B. Fan, and S. Zhang, Phys. Rev. A 73, 022338 (2006).
19、Remote preparation of the N-particle GHZ state using quantum statistics
Y. Xia, J. Song, and H. S. Song, Opt. Commun. 277, 219 (2007).
20、Quantum computation and entangled state generation through adiabatic evolution in two distant cavities
J. Song, Y. Xia, H. S. Song, J. L. Guo, and J. Nie, Europhys. Lett. 80, 60001 (2007).
21、 Joint remote state preparation of a W-type state via W-type states,
Q. Q. Chen,Y. Xia*, J. Song, N. B. An, Phys. Lett. A 374, 4483-4487 (2010).
22、Controlled implementation of two-photon controlled phase gate within a network,
Y. Xia,et al.,Quan. Inf. Comput. 10, 0821-0828 (2010).
23、Generation of four-photon polarization-entangled decoherence-free states within a network,
Y. Xia, et al., Appl. Phys. B 99, 651-656 (2010).
24、Efficient implementation of the two-qubit controlled phase gate with cross-Kerr nonlinearity,
Y. Xia, et al., J. Phys. B: At. Mol.Opt. Phys. 44, 079804 (2011).
25、Effective quantum teleportation of an atomic state between two cavities with the cross-Kerr nonlinearity by interference of polarized photons
Y. Xia, J. Song, P M. Lu, and H. S. Song, J. Appl.Phys. 109, 103111 (2011).
26、Fault tolerant analog search algorithm within a quantum network J. Song, X. D. Sun, Y. Xia, and H. S. Song, J. Phys. B: At. Mol. Opt. Phys. 44, 115503 (2011).
27、Efficient creation of continuous variable entanglement for two atomic ensembles in coupled cavities
J. Song, X. D. Sun, Y. Xia, and H. S. Song, Phys. Rev. A 83, 052309 (2011).2. 青岛理工大学教授
夏岩，博士，1957年出生，青岛理工大学教授，山东省“泰山学者海外特聘专家”。 1982年毕业于南开大学有机化学专业，获学士学位；1989年于美国匹兹堡大学有机合成专业，获博士学位。攻读博士学位期间，在世界上首次完成了天然产物石杉碱的全合成。1989-1990年在美国健康研究所从事博士后研究工作。1990年到2011年，在美国仙灵保雅制药公司（与默克公司合并）工作，先后担任资深研究员、副骨干研究员、骨干研究员、2000年开始担任资深骨干研究员（Senior Principal Scientist），学术兼职为美中医药开发协会秘书长。从事新药开发工作，参与研发降血压、抗心血管病，糖尿病，中枢神经，肝炎等新药十余种。主要代表性成果有：1) 抗血凝新药-凝血酶受体拮抗剂，现在三期临床测试。2008年荣获爱迪生(Thomas Alva Edison) 发明奖；1996、2003年二获科研所长奖(President’s Award)。 2) 帕金森病新药-A2a受体拮抗剂，现在二期临床测试， 2009年获爱迪生(Thomas Alva Edison) 发明奖。 目前申请专利29项，发表学术论文28篇。
研究方向：
心血管新药的研发
代表论文：
1. Discovery of nor-seco himbacine analogs as thrombin receptor antagonists. Bioorganic & Medicinal Chemistry Letters, Available online 16 February 2012.
2. Discovery of a Nortropanol Derivative as a Potent and Orally Active GPR119 Agonist for Type 2 Diabetes. Bioorganic & Medicinal Chemistry Letters 2011, 21, 3290-3296.
3. Discovery of a vorapaxar analog with increased aqueous solubility. Bioorganic & Medicinal Chemistry Letters 2010, 20, 6676-6679.
4. The role of exploratory drug metabolism and pharmacokinetics in new drug research: case study-selection of a Thrombin Receptor Antagonist for development . Current Pharmaceutical Design, 2009, 15, 2262-2269.
5. Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity. Journal of Medicinal Chemistry; 2008, 51, 3061-3064.
6. Heterotricyclic Himbacine Analogs as Potent, Orally Active Thrombin Receptor (Protease Activated Receptor-1) Antagonists. Journal of Medicinal Chemistry, 2007, 50, 5147-5160.
7. Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring. Bioorganic & Medicinal Chemistry Letters 2007, 17, 4509-4513.
8. Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core. Bioorganic & Medicinal Chemistry Letters 2007, 17, 3647-3651.
9. Metabolism-Based Identification of a Potent Thrombin Receptor Antagonis. Journal of Medicinal Chemistry 2007, 50, 129-138.
10. Himbacine derived thrombin receptor (PAR-1) antagonists: Structure-activity relationship of the lactone ring. Bioorganic & medicinal chemistry letters 2006, 16, 4969-4972.
11. Thrombin receptor (PAR-1) antagonists as novel antithrombotic agents. Expert Opinion on Therapeutic Patents 2006, 16, 493-505.
12. Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists. Bioorganic & Medicinal Chemistry Letters 2006, 16, 1544
13. Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents. Journal of Medicinal Chemistry 2005, 48, 5884-5887.
专利：
1. Bicyclic heterocycle derivatives and their use as gpcr modulators. WO 20100092072.
2. Preparation of heterocyclic compounds as factor IXa inhibitors. WO 2009143039
3. Combination therapies comprising PAR1 antagonists with PAR4 antagonists for treatment of diseases assocd. with thrombosis. WO 2009124103
4. Bicyclic heterocycle derivatives and methods of use thereof. WO 2009055331
5. Preparation of bicyclic and tricyclic himbacine derivatives as thrombin receptor antagonists. WO 2008042422
6. Preparation of bicyclic and tricyclic himbacine derivatives as thrombin receptor antagonists. US 2008004318
7. Fused ring thrombin receptor antagonists. US 2007244163
8. Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists. US 2007232635
9. Diaryl piperidines as CB1 modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO 2007084319
10. Spiroheterocyclic-decalin compounds as thrombin receptor antagonists and their preparation and pharmaceutical compostions. WO 2006105217
11. Preparation of himbacine analogs for use in pharmaceutical compositions as thrombin receptor antagonists. US 2006079684
12. Preparation of constrained himbacine analogs as thrombin receptor antagonists. US 2005267155
13. Preparation of aminohydroxyalkyl cyclic amine BACE-1 inhibitors having a benzamide substituent. WO 2005016876
14. Tricyclic thrombin receptor antagonists. WO 2003089428
14. Adenosine A2a receptor antagonists. WO20010192264